Cassiopeia Splash Art
Cassiopeia

Cassiopeia Synergies Patch 16.16: Best and Worst Picks with Cassiopeia

Find the best champions to pair with Cassiopeia for Mid Lane using win rate data on LoLTheory. Optimize your team composition in LoL Season 16 Patch 16.16.

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Based on the typical player's experience with each champion—e.g., the average Vayne player has more games with Vayne than the average Ahri player has with Ahri

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Maximize your next game's win rate by analyzing your ranked history—performance and game count—for all champions over the last 10 patches.

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Best Picks with Cassiopeia

Champions that perform well alongside Cassiopeia in team compositions. Listed by highest win rates when paired with Cassiopeia in Platinum ranked matches.
ChampionRoleWR%
NautilusNautilus5.77% PR 56.99% Jarvan IVJarvan IV4.81% PR 56.41% TristanaTristana3.85% PR 55.69% LuluLulu8.65% PR 55.40% OrnnOrnn3.53% PR 53.66% ViVi3.53% PR 53.05% LeonaLeona3.53% PR 52.17% KarmaKarma5.13% PR 51.67% YunaraYunara5.77% PR 51.18% OlafOlaf3.53% PR 49.97% RenektonRenekton4.81% PR 49.84% Kai'SaKai'Sa12.82% PR 49.78% JinxJinx7.37% PR 49.72% NasusNasus4.49% PR 49.36% AatroxAatrox3.85% PR 49.14% KaynKayn4.17% PR 49.14% PykePyke5.13% PR 49.13%

Worst Picks with Cassiopeia

Champions that underperform when paired with Cassiopeia. Ranked by lowest win rates when on the same team in Platinum matches.
ChampionRoleWR%
NamiNami3.85% PR 43.40% Dr. MundoDr. Mundo4.17% PR 44.35% JhinJhin6.73% PR 44.42% GravesGraves7.05% PR 44.71% ZedZed3.53% PR 44.71% TalonTalon3.53% PR 45.37% LucianLucian6.09% PR 45.41% BardBard3.85% PR 45.67% ThreshThresh7.05% PR 45.97% JaxJax4.17% PR 47.05% BraumBraum3.53% PR 47.80% CaitlynCaitlyn7.05% PR 48.18% EzrealEzreal10.90% PR 48.32% Lee SinLee Sin7.69% PR 48.79% YoneYone7.37% PR 48.81% CamilleCamille3.53% PR 48.90% ViegoViego5.77% PR 49.08%
Learn how to play with Cassiopeia with these essential tips.
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When Cassiopeia lands her R (Petrifying Gaze), position on the opposite side of the target from her — enemies facing her get stunned, but those facing away only get slowed, so a coordinated flank locks down more targets.
Team Fight
Cassiopeia's W (Miasma) grounds everyone caught in the poison cloud, blocking dashes, blinks, and Flash — follow up immediately with skillshots or all-ins while enemies can't reposition.
Team Fight Skirmish
Cassiopeia's E (Twin Fang) only deals its bonus damage and heals significantly against poisoned enemy champions — engage or follow up right after she lands Q or W, since that's her peak damage window.
Basic Skirmish Team Fight
Cassiopeia has no dash, blink, or other mobility tool — her passive amplifies all movement speed bonuses — so she can't peel for herself or escape a dive. Prioritize covering her lane, since she has no way to disengage on her own.
Basic Lane Phase
Her R (Petrifying Gaze) has a long cooldown early in the game — once she uses it to engage or peel, expect a long wait before it's up again. Plan fights around that window.
Advanced Team Fight
Cassiopeia typically maxes E first, giving her a real level 2 all-in off Q and E — she snowballs hard off an early kill, so look to assist her lane before she's forced to fall behind.
Lane Phase
Cassiopeia scales into one of the strongest late-game champions — help her farm safely even if she falls behind early, since her damage output climbs sharply as she stacks items.
Basic Late Game